The BTX Caliper Electrodes are in vivo style re-usable electrodes that
are used for a variety of applications. Caliper Electrodes come in two
models, with each model consisting of a caliper and a pair of end plates.
Model 384 are used for smaller animals with a smaller surface area, while
model 384L is used to target slightly larger surface areas. The end plates
of the Caliper Electrode may be adjusted by using the black roller mounted
on the caliper. Caliper Electrodes may be cleaned with a mild detergent and
sterilized with ethanol or ethylene oxide. Properly maintained Caliper
Electrodes have an unlimited life, and are compatible with most BTX
Electroporation Systems.
Caliper Electrodes may be used for many electroporation applications,
including drug and gene delivery. The electrodes span the target area
following injection of the molecule of interest, and electroporation pulses
are delivered using a BTX Electroporation System, such as the ECM 600,
ECM 630, ECM 830, ECM 2001, or T820. The electric field introduced by
the Caliper Electrodes cause transient pores to form in the cells of
the tissue, allowing uptake of the molecules into the cells. Prud'Homme
et al. used the Caliper electrodes to deliver plasmid DNA to skin for
gene therapy studies on diabetes.1 Mir et al. used the Caliper Electrode
for in vivo skeletal muscle work2 as well as subcutaneous tumor
electrochemotherapy applications3. Caliper Electrodes can potentially be
used for intact plant work as well.4
Caliper Electrodes complement BTX Tweezertrodes Model 520, 522; BTX
Genetrodes Model 508(S) and 510(S); and BTX 2 Needle Array Electrodes Model
530, 531, 532, 533 as part of the BTX in vivo electrode line. Caliper
Electrodes can be used to reproduce applications requiring Tweezertrodes
(transdermal) and Genetrodes/2-Needle.
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| Standard Capabilities |
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Voltage Range: |
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0-500V DC(depending on electrode gap) |
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Pulse Length Range: |
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1mses-10msec |
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Pulse Number Range: |
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1-99 (depending on voltage) |
| Physical Characteristics |
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Model 384 Electrode Dimensions:
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1.0cm x 1.0cm |
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Model 384L Electrode Dimensions: |
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2.0cm x 2.0cm (1.5cm x 1.5cm spare pair included) |
| Electrode Material: |
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Stainless Steel |
| Generator Compatibility: |
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ECM 830, 600, 630, 2001, T820 |
| Electrode gap: |
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0.1-13cm |
| System Model |
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Available Configurations |
| 384 |
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Caliper Electrodes, 1.0cm x 1.0cm Brass Plates |
| 384L |
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Caliper Electrodes, 2.0cm x 2.0cm Stainless Steel Plates (1.5cm x 1.5cm spare pair included) |
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- Prud'Homme et al., Human Gene Therapy, 13: 395-406 (2002)
- Mir et al., PNAS, 96, 4262-4267 (1999)
- Mir et al., British Journal of Cancer, 77(12), 2336-2342 (1998)
- Dev et al., U.S. Patent 5,859,327 Jan 12, 1999
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