AgilePulse Needle Array Electrodes are miniature needles designed to provide superior, highly-uniform electric fields in dermal or muscular tissue as part of the AgilePulse in vivo Gene Delivery Electroporation System. Applications for these electrodes include intra-dermal DNA vaccine research and antibody production, cancer chemotherapy research or intra-muscular gene therapy. The miniature parallel-needle array is inserted directly into the target site for fast, reliable in vivo electroporation. The electric fields produced are the closest approximation of parallel plate electrodes, treating approximately 80% of the target area with 95% of the applied electric field. The Needle Array requires the Needle Array handle which includes the Electrode Connector cable. Several needle lengths and row spacing are available for various intra-dermal or intra-muscular applications. Needle Arrays can be used for up to 500 pulses with proper care and maintenance.
NEEDLE ARRAY DESIGN
- Uniform, reliable electric fields
- Miniature needles minimize tissue trauma
- Disposable, sterile
- Medical-grade plastic and surgical steel construction
- Safety-assured design
- Multiple configurations and sizes to choose
Use of the AgilePulse HT system (formerly Cyto LVT-P) is subject to an annual license agreement between Cellectis bioresearch and the purchaser. Please contact Cellectis bioresearch email@example.com for further details.
Use of the AgilePulse In Vivo system (formerly the DermaVax device) is not authorized for any veterinary and human therapeutic uses. Contact Cellectis therapeutics firstname.lastname@example.org for such uses.
INTRA DERMAL NEEDLE ARRAYS
|Needle Material||Stainless Steel||Stainless Steel||Stainless Steel||Stainless Steel||Stainless Steel|
|Needle Tip||Fine Point||Fine Point||Fine Point||Fine Point||Fine Point|
|Spacing in Row||1.5 mm||1.5 mm||1.5 mm||1.5 mm||1.5 mm|
|Spacing Between Rows||4 mm||4 mm||4 mm||4 mm||4 mm|
|Needles per Row||4||3||4||6||6|
|Needle Diameter||0.3 mm||0.3 mm||0.3 mm||0.3 mm||0.3 mm|
|Needle Length||2 mm||3 mm||5 mm||2 mm||5 mm|
INTRA MUSCULAR NEEDLE ARRAYS
|Needle Material||Stainless Steel||Stainless Steel||Stainless Steel|
|Needle Tip||Fine Point||Trocar Point||Trocar Point|
|Spacing in Row||1.5 mm||1.5 mm||1.5 mm|
|Spacing Between Rows||6 mm||6 mm||6 mm|
|Needles per Row||6||6||6|
|Needle Diameter||0.3 mm||0.7 mm||0.7 mm|
|Needle Length||10 mm||25 mm||16 mm|
- DNA Vaccine Delivery
- Cancer Vaccine Research
- Intra-dermal Transfection
- Gene Therapy Research
- Intra-muscular Gene Delivery
- Chemotherapeutic Research
Lundberg K, Roos A-K, Pavlenko M, Wehrum D, Pisa P. Peptide specificity of HLA-A2-restricted CD8+ T cell responses induced with DNA vaccines coding for human and rhesus PSA. Vaccine. 2009 Mar 4;27(10):1557-65. Epub 2009. Jan 24 Br
Bråve A, Hallengärd D, Gudmundsdotter L, Stout R, Walters R, Wahren B, Hallermalm K. Late administration of plasmid DNA by intradermal electroporation efficiently boosts DNA-primed T and B cell responses to carcinoembryonic antigen. Vaccine. 2009 Jun 8;27(28):3692-6. Epub 2009 May 3.
Roos, A-K, Eriksson, F, Walters, D, Pisa, P, King, A. Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patients. Molecular Therapy, 2009 Sep;17(9):1637-42. Epub 2009 Jun 16.
Lladser A, Ljungberg K, Tufvesson H, Tazzari M, Roos A, Quest FG, Kiessling R. Intradermal electroporation with a survivin DNA vaccine induces CTLs against a self-epitope, suppresses angiogenesis and confers long-term protection against mouse.